Here's
a simple script for generating rotamers. It assumes the input geometry is reasonable and perturbs the dihedral angles of $n$ rotateable bonds by $\pm 120^\circ$. It makes all $3^n$ combinations of dihedral angles but if that is larger than a user-defined cutoff it will pick a random subset. Rotateable bonds include alcohol, phenols, and primary amines, but also amide bonds. It doesn't know about equivalent atoms, so it will happily rotate a tert-butyl or trifluoromethyl group.
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